' 
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.1
USERS' SCORE
Good
Based on 2 Reviews
8.2
Supplement Facts
Serving Size: 4 Capsules
Serving Per Container: 30
Amount Per Serving
%DV
Vitamin C (from culture of S. cerevisiae)
50 mg
56%
Vitamin D (as D3 from culture of S. cerevisiae)
40 mcg (1,600 IU)
200%
Vitamin K (from culture of S. cerevisiae)
120 mcg
100%
Calcium (naturally occurring from Algae)
1,100 mg
85%
Magnesium (from Algae and Dead Sea minerals)
357 mg
85%
Vitamin K (as K2 MK-7)
50 mcg
+
Strontium (naturally occurring from Algae)
3.8 mg
+
Boron (from Brown Rice Chelate)
3 mg
+
Silica (naturally occurring from Algae)
2.2 mg
+
Vanadium (naturally occurring from Algae)
25 mcg
+
Raw Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus bulgaricus, Lactobacillus plantarum] (500 Million CFU).
64 mg
+
Top Medical Research Studies
7
Vitamin D's role in sleep apnea
Sleepiness and Vitamin D Levels in Patients with Obstructive Sleep Apnea.
Significant findings on Vitamin D
We aimed to explore the connection between Vitamin D levels and excessive daytime sleepiness in patients diagnosed with obstructive sleep apnea (OSA). In this study, we analyzed serum Vitamin D levels in a group of newly diagnosed OSA patients, dividing them into two categories: those who experienced excessive daytime sleepiness (EDS) and those who did not.
Our findings indicated that patients with EDS had significantly lower levels of Vitamin D compared to their non-somnolent counterparts. The study showed that lower Vitamin D levels correlated with higher apnea-hypopnea indices (AHI) and lower oxyhemoglobin saturation during sleep. This suggests that sleep-related hypoxia may impact Vitamin D status and contribute to sleepiness.
Moreover, our analysis indicated that lower Vitamin D levels were independent predictors of EDS. This further emphasizes the potential role of Vitamin D in managing sleep quality for these patients. In summary, our study highlights an important association between Vitamin D levels and daytime sleepiness in people with sleep apnea, suggesting that improving Vitamin D status could be beneficial for managing EDS in these individuals.
Our findings indicated that patients with EDS had significantly lower levels of Vitamin D compared to their non-somnolent counterparts. The study showed that lower Vitamin D levels correlated with higher apnea-hypopnea indices (AHI) and lower oxyhemoglobin saturation during sleep. This suggests that sleep-related hypoxia may impact Vitamin D status and contribute to sleepiness.
Moreover, our analysis indicated that lower Vitamin D levels were independent predictors of EDS. This further emphasizes the potential role of Vitamin D in managing sleep quality for these patients. In summary, our study highlights an important association between Vitamin D levels and daytime sleepiness in people with sleep apnea, suggesting that improving Vitamin D status could be beneficial for managing EDS in these individuals.
Read More
7
Vitamin D's role in sleep apnea
Associations between Vitamin D Status and Polysomnographic Parameters in Adults with Obstructive Sleep Apnea.
Direct study of vitamin D effects
We explored the connection between vitamin D levels and obstructive sleep apnea (OSA) severity in a group of 262 adults who were diagnosed with OSA through polysomnography (a type of sleep study). Our aim was to understand if vitamin D deficiency could influence the severity of sleep apnea symptoms, particularly given the growing evidence linking these two health issues.
In our findings, we observed that 63% of participants had low vitamin D levels, which were associated with increased severity of OSA. The results showed a negative correlation between vitamin D levels and key sleep parameters, meaning that lower vitamin D was linked to worse apnea-hypopnea indices, which measure the frequency of breathing interruptions.
Notably, when we adjusted for various factors like age, sex, and body mass index, our analysis revealed that individuals with higher vitamin D levels had lower chances of experiencing severe OSA. Conversely, those with vitamin D deficiency were nearly three times more likely to have severe symptoms, particularly in individuals over 50 or those categorized as obese.
This study suggests that maintaining adequate vitamin D levels might be important in managing OSA severity. However, it’s essential to note that we did not specifically examine the effects of vitamin D treatment, so more research is needed to determine whether increasing vitamin D can effectively improve sleep apnea outcomes.
Overall, our work highlights the potential role of vitamin D as a modifiable factor in the complex management of obstructive sleep apnea and its symptoms.
In our findings, we observed that 63% of participants had low vitamin D levels, which were associated with increased severity of OSA. The results showed a negative correlation between vitamin D levels and key sleep parameters, meaning that lower vitamin D was linked to worse apnea-hypopnea indices, which measure the frequency of breathing interruptions.
Notably, when we adjusted for various factors like age, sex, and body mass index, our analysis revealed that individuals with higher vitamin D levels had lower chances of experiencing severe OSA. Conversely, those with vitamin D deficiency were nearly three times more likely to have severe symptoms, particularly in individuals over 50 or those categorized as obese.
This study suggests that maintaining adequate vitamin D levels might be important in managing OSA severity. However, it’s essential to note that we did not specifically examine the effects of vitamin D treatment, so more research is needed to determine whether increasing vitamin D can effectively improve sleep apnea outcomes.
Overall, our work highlights the potential role of vitamin D as a modifiable factor in the complex management of obstructive sleep apnea and its symptoms.
Read More
7
Vitamin D and sleep apnea explored
Exploring the link between vitamin D deficiency and obstructive sleep apnea: A comprehensive review.
Relevant study on treatment effects
We delved into the intriguing link between vitamin D deficiency and obstructive sleep apnea (OSA). Our investigation revealed that many individuals with OSA also struggle with low vitamin D levels, no matter where they are located around the globe. This finding suggests that there may be underlying factors contributing to vitamin D deficiency beyond just insufficient sunlight exposure.
Furthermore, we observed that reduced levels of vitamin D might correlate with more severe cases of OSA. This led us to consider whether boosting vitamin D levels through supplementation could serve as a potential treatment for OSA. Notably, some studies pointed out that patients who took vitamin D supplements reported improvements in sleep quality and a decrease in the severity of their OSA symptoms.
We proposed several potential mechanisms for how vitamin D might influence OSA. These included its role in reducing inflammation and oxidative stress, improving immune function, affecting muscle function, and even involving genetic factors related to vitamin D receptors. However, we underline the need for further research to better understand these connections and to figure out the best dosages and treatment durations for vitamin D supplementation.
Furthermore, we observed that reduced levels of vitamin D might correlate with more severe cases of OSA. This led us to consider whether boosting vitamin D levels through supplementation could serve as a potential treatment for OSA. Notably, some studies pointed out that patients who took vitamin D supplements reported improvements in sleep quality and a decrease in the severity of their OSA symptoms.
We proposed several potential mechanisms for how vitamin D might influence OSA. These included its role in reducing inflammation and oxidative stress, improving immune function, affecting muscle function, and even involving genetic factors related to vitamin D receptors. However, we underline the need for further research to better understand these connections and to figure out the best dosages and treatment durations for vitamin D supplementation.
Read More
Most Useful Reviews
7.5
Improved sleep quality
I took this upon recommendation due to the belief that calcium deficiency can affect the quality of sleep. I've repurchased it and am taking it again as I believe calcium enhances my sleep more than other nutrients.
Read More
6.3
Enhanced sleep support
I bought this on a pharmacist's recommendation. I'm taking only two pills due to the high calcium content. It helps me sleep well, and I intend to continue using it regularly.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.1
- All Researches
9.5
Weight loss improves vitamin D levels
Impact of weight loss and lifestyle intervention on vitamin D in men with obstructive sleep apnea: The INTERAPNEA trial.
Study limitations reduce vitamin D impact
We embarked on an intriguing study to see how an eight-week weight loss and lifestyle intervention could influence vitamin D levels in men suffering from obstructive sleep apnea (OSA). Our group of 89 men was split into two; one group received usual care, while the second group engaged in the lifestyle program alongside their standard treatment.
After this intervention, we observed some promising results regarding vitamin D levels. Specifically, the intervention group showed a significant increase in serum 25-hydroxyvitamin D (25(OH)D) levels, with improvements noted at both the end of the 8 weeks and six months later. Indeed, their vitamin D deficiency was potentially resolved.
Moreover, we found that these higher vitamin D levels correlated with better sleep quality, as evidenced by increased sleep efficiency and improvements in several sleep metrics, such as the apnea-hypopnea index (AHI) and oxygen desaturation index. Additionally, body composition measurements, including fat mass, also showed positive changes.
In conclusion, our findings suggest that a coordinated approach combining weight loss and lifestyle changes can be beneficial not just for vitamin D status, but also for overall health aspects related to obstructive sleep apnea.
After this intervention, we observed some promising results regarding vitamin D levels. Specifically, the intervention group showed a significant increase in serum 25-hydroxyvitamin D (25(OH)D) levels, with improvements noted at both the end of the 8 weeks and six months later. Indeed, their vitamin D deficiency was potentially resolved.
Moreover, we found that these higher vitamin D levels correlated with better sleep quality, as evidenced by increased sleep efficiency and improvements in several sleep metrics, such as the apnea-hypopnea index (AHI) and oxygen desaturation index. Additionally, body composition measurements, including fat mass, also showed positive changes.
In conclusion, our findings suggest that a coordinated approach combining weight loss and lifestyle changes can be beneficial not just for vitamin D status, but also for overall health aspects related to obstructive sleep apnea.
Read More
8
Vitamin D may reduce OSA risk
Relationship of serum 25-hydroxyvitamin D, obesity with new-onset obstructive sleep apnea.
Moderate relevance to vitamin D treatment
We embarked on a large-scale study to understand how vitamin D influences obstructive sleep apnea (OSA), especially in those who are obese. Analyzing data from nearly 445,000 participants from the UK Biobank, we focused on individuals who had no previous diagnosis of OSA. The key outcome was the development of new cases of OSA over an average follow-up of 12 years.
What we found was intriguing: higher serum levels of 25-hydroxyvitamin D, the main form of vitamin D in the bloodstream, were associated with a reduced risk of developing new-onset OSA, particularly in participants struggling with obesity. Those with both a body mass index (BMI) of 25 or higher and waist circumference measurements of 90 cm or more showed a significant inverse relationship. This suggests that those with these characteristics might benefit more from maintaining higher vitamin D levels.
The results indicate that while vitamin D supplementation on its own wasn't tested, our findings certainly highlight its potential role in preventing OSA, particularly in at-risk populations. It's a reminder of the importance of monitoring and maintaining adequate vitamin D levels, especially for those dealing with obesity.
What we found was intriguing: higher serum levels of 25-hydroxyvitamin D, the main form of vitamin D in the bloodstream, were associated with a reduced risk of developing new-onset OSA, particularly in participants struggling with obesity. Those with both a body mass index (BMI) of 25 or higher and waist circumference measurements of 90 cm or more showed a significant inverse relationship. This suggests that those with these characteristics might benefit more from maintaining higher vitamin D levels.
The results indicate that while vitamin D supplementation on its own wasn't tested, our findings certainly highlight its potential role in preventing OSA, particularly in at-risk populations. It's a reminder of the importance of monitoring and maintaining adequate vitamin D levels, especially for those dealing with obesity.
Read More
7
Vitamin D3 aids OSA treatment
Unveiling the benefits of Vitamin D3 with SGLT-2 inhibitors for hypertensive obese obstructive sleep apnea patients.
Combination therapy relevance noted
We conducted a study aimed at understanding how vitamin D3 might influence obstructive sleep apnea (OSA), particularly in hypertensive, obese patients. The research carefully examined the potential benefits of combining vitamin D3 with a medication called Dapagliflozin, a type of SGLT-2 inhibitor known for its additional cardiovascular advantages.
Over 16 weeks, participants were divided into four groups: those receiving Dapagliflozin, those receiving vitamin D3, those receiving both treatments, and a control group that received no treatment. We looked at a range of health parameters, including weight, blood sugar levels, and quality of life scores, to assess the overall impact of these treatments.
Our findings revealed positive outcomes from using vitamin D3 alongside SGLT-2 inhibitors, suggesting that this combination therapy could help improve cardiac and metabolic health, as well as quality of life in patients struggling with OSA. However, we acknowledged the need for further studies to isolate the specific effects of vitamin D on sleep apnea independently from the benefits provided by the medication.
Over 16 weeks, participants were divided into four groups: those receiving Dapagliflozin, those receiving vitamin D3, those receiving both treatments, and a control group that received no treatment. We looked at a range of health parameters, including weight, blood sugar levels, and quality of life scores, to assess the overall impact of these treatments.
Our findings revealed positive outcomes from using vitamin D3 alongside SGLT-2 inhibitors, suggesting that this combination therapy could help improve cardiac and metabolic health, as well as quality of life in patients struggling with OSA. However, we acknowledged the need for further studies to isolate the specific effects of vitamin D on sleep apnea independently from the benefits provided by the medication.
Read More
7
Vitamin D's role in sleep apnea
Sleepiness and Vitamin D Levels in Patients with Obstructive Sleep Apnea.
Significant findings on Vitamin D
We aimed to explore the connection between Vitamin D levels and excessive daytime sleepiness in patients diagnosed with obstructive sleep apnea (OSA). In this study, we analyzed serum Vitamin D levels in a group of newly diagnosed OSA patients, dividing them into two categories: those who experienced excessive daytime sleepiness (EDS) and those who did not.
Our findings indicated that patients with EDS had significantly lower levels of Vitamin D compared to their non-somnolent counterparts. The study showed that lower Vitamin D levels correlated with higher apnea-hypopnea indices (AHI) and lower oxyhemoglobin saturation during sleep. This suggests that sleep-related hypoxia may impact Vitamin D status and contribute to sleepiness.
Moreover, our analysis indicated that lower Vitamin D levels were independent predictors of EDS. This further emphasizes the potential role of Vitamin D in managing sleep quality for these patients. In summary, our study highlights an important association between Vitamin D levels and daytime sleepiness in people with sleep apnea, suggesting that improving Vitamin D status could be beneficial for managing EDS in these individuals.
Our findings indicated that patients with EDS had significantly lower levels of Vitamin D compared to their non-somnolent counterparts. The study showed that lower Vitamin D levels correlated with higher apnea-hypopnea indices (AHI) and lower oxyhemoglobin saturation during sleep. This suggests that sleep-related hypoxia may impact Vitamin D status and contribute to sleepiness.
Moreover, our analysis indicated that lower Vitamin D levels were independent predictors of EDS. This further emphasizes the potential role of Vitamin D in managing sleep quality for these patients. In summary, our study highlights an important association between Vitamin D levels and daytime sleepiness in people with sleep apnea, suggesting that improving Vitamin D status could be beneficial for managing EDS in these individuals.
Read More
7
Vitamin D and sleep apnea explored
Exploring the link between vitamin D deficiency and obstructive sleep apnea: A comprehensive review.
Relevant study on treatment effects
We delved into the intriguing link between vitamin D deficiency and obstructive sleep apnea (OSA). Our investigation revealed that many individuals with OSA also struggle with low vitamin D levels, no matter where they are located around the globe. This finding suggests that there may be underlying factors contributing to vitamin D deficiency beyond just insufficient sunlight exposure.
Furthermore, we observed that reduced levels of vitamin D might correlate with more severe cases of OSA. This led us to consider whether boosting vitamin D levels through supplementation could serve as a potential treatment for OSA. Notably, some studies pointed out that patients who took vitamin D supplements reported improvements in sleep quality and a decrease in the severity of their OSA symptoms.
We proposed several potential mechanisms for how vitamin D might influence OSA. These included its role in reducing inflammation and oxidative stress, improving immune function, affecting muscle function, and even involving genetic factors related to vitamin D receptors. However, we underline the need for further research to better understand these connections and to figure out the best dosages and treatment durations for vitamin D supplementation.
Furthermore, we observed that reduced levels of vitamin D might correlate with more severe cases of OSA. This led us to consider whether boosting vitamin D levels through supplementation could serve as a potential treatment for OSA. Notably, some studies pointed out that patients who took vitamin D supplements reported improvements in sleep quality and a decrease in the severity of their OSA symptoms.
We proposed several potential mechanisms for how vitamin D might influence OSA. These included its role in reducing inflammation and oxidative stress, improving immune function, affecting muscle function, and even involving genetic factors related to vitamin D receptors. However, we underline the need for further research to better understand these connections and to figure out the best dosages and treatment durations for vitamin D supplementation.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved sleep quality
I took this upon recommendation due to the belief that calcium deficiency can affect the quality of sleep. I've repurchased it and am taking it again as I believe calcium enhances my sleep more than other nutrients.
6.3
Enhanced sleep support
I bought this on a pharmacist's recommendation. I'm taking only two pills due to the high calcium content. It helps me sleep well, and I intend to continue using it regularly.
